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KMID : 0644120020150040017
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Journal of Oriental Gynecology
2002 Volume.15 No. 4 p.17 ~ p.31
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Effects of Caraganae Sinicae Radix on the osteoporosis in ovariectomized rats
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Kim Hyung-Jun
Lee Dong-Nyung
Seo Il-Bok
Hwang Jeong-Seon
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Abstract
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Objective : This study was carried out to investigate the effects of the hormones and cytokines associated with bone metabolism in ovariectomized rats.
Method : Twenty-four Female-Sprague-Dawley rats were divided into sham operated(normal) group, ovariectomized(control)group, ovariectomized and treated with extract Caraganae Sinicae Radix(treated) group. Each group was investigated the changes of body weight at 3,5,7weeks after treatment, and femur weight, femur/body weight, thickness of compact bone of body of femur, area of cancellous bone of distal epiphysis of femur, serum estrogen, serum calcitonin, serum parathormone, serum Tumor Necrosis Factor-{alpha}, serum lnterleukin-1{beta} at 7weeks after treatment. The results were summerized as follows; 1. The treated group showed significant change in body weight compared with the control group at 5,7weeks after treatment. 2. The treated group revealed significant increases in femur/body weight compared with the control group. 3. The treated group showed a little thicker compact bone of body of femur than the control group. 4. The area of cancellous bone of distal epiphysis of femur in treated group was increased significantly compared with control group. 5. The level of serum estrogen showed no change compared with control group. 6. The level of serum calcitonin showed no change compared with control group. 7. The level of serum parathormone was decreased in treated group significantly compared with control group. 8. The level of serum TNF-{alpha} was decreased in treated group significantly compared with control group. 9. The level of serum interleukin-1{beta} showed no change compared with control group. The results indicate that Caraganae Sinicae Radix inhibits bones resorption in ovariectomized rats by it’’s lowering effects on serum parathormone and TNF-{alpha}.
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KEYWORD
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Caraganae Sinicae Radix, Osteoporosis, parathormone, TNF-{\alpha}
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